Endocrine Abstracts

Introduction: Suppurative meningitis (SM) is a life threatening disease. It is rarely observed as a primary presentation in large pituitary tumours (PT) destroying the sellar floor and/or invading the skull base. Our aim is to report 3 SM revealing macroprolactinomas.Case No. 1: A man aged 22, consulted for vomiting and fever. The diagnosis of SM was confirmed by lumbar puncture and blood cultures. Cerebral MRI showed multidirectional PT invading caverno...

Introduction: Acromegaly is a relatively rare disease with numerous complications. Our aim is to look for visceral abnormalities and tumour development in subjects with GH and insuIin like GH (or IGF1) excess.Subjets and methods: It is a retro-and prospective study that takes in account 112 patients at diagnosis, with pur pituitary tumours secreting GH, or mixed tumours secreting prolactin and GH diagnosed between 1980 and 2012. They all were questioned ...

Introduction: Generously supported by IPSEN)-->Pituitary tumours are known to cause headaches and visual troubles by compressing pituitary adjacent structures. Pressure on more distant structures is exceptional. In very large tumours such as prolactinomas, mixed adenomas or craniopharyngiomas, hydrocephalus, convulsions, memory troubles and even unconsciousness can be observed, but to our best knowledge motor deficits, such as hemipl...

Introduction: Prolactinomas are more invasive in males. Giant ones (height ≥4 cm) are relatively rare in literature.Our aim is to analyze their frequency, their radiological aspects, and their neurological, endocrine and ophthalmological complications.Methods: All of them had clinical exam, hormonal, ophthalmological, and radiological assessment based on cerebral MRI. Mixed adenomas were excluded. Positive diagnosis was based...

Introduction: Glucose metabolism disorders are well known in subjects with GH excess, but little is known about other metabolic abnormalities. Our aim is to analyze metabolic complications in subjects with acromegaly and pituitary gigantism.Subjects and methods: Records of 111 subjects were retrospectively examined, mean GH=62 ng/ml (n<5), mean age=39.11 (14–60). All had routine analysis for fasting blood glucose, cholesterol, triglycer...

Introduction: Pituitary adenomas in general are deemed to be more aggressive in males. Our aim is to analyze somatotrop adenomas (SA) characteristics and neurological complications. In the second time we will compare male and female cases.Subjects and methods: In this retro-and prospective study, 112 pure and mixed SA diagnosed between 1980 and 2012 were analyzed. They all had hormonal assessment (GH before and after OGTT±IGF1, PRL, cortisol, ACTH, ...

Introduction: Non functioning pituitary adenomas (NFPA) frequency varies from 15 to 30% among all pituitary adenomas. Some authors think they are more aggressive and at risk of pituitary apoplexy. Our aim is to analyze their characters and their complications.Subjects and methods: It is a retrospective study that takes in account 37 subjects having a NFPA and recruited from 2005 to 2012. Among this group only 13 have been operated on and had immunochemic...